
The Role of Desmopressin in Managing Bedwetting
Explore the role of desmopressin in managing bedwetting. Learn about its mechanisms, forms, and side effects, and discover a holistic approach for effective treatment.
If you’re dealing with wet sheets, broken sleep, and a child who just wants to wake up dry, you’re not alone. Bedwetting can feel like a jigsaw puzzle—one where you’re missing a few pieces and doing your best to figure it out in the dark.
One often-overlooked piece of the puzzle is the brain–bladder connection—the way your child’s body learns to recognise and respond to the need to wee at night. Understanding how your child’s brain and bladder work together is often the first step toward helping them stop bedwetting.
The brain and bladder need to communicate clearly. When the bladder fills with urine, it sends a message to the brain: “I’m full.” The brain’s job is to respond—either by helping the bladder hold on or by waking your child so they can go to the toilet.
For many children, especially those whose internal systems are still developing, that message doesn’t always get through. It’s not about laziness or bad habits. It’s simply that the brain and bladder connection hasn’t been switched on yet.
If your child is still wearing a nappy or being woken during the night to use the toilet, the brain-bladder signalling doesn’t get much practice—because that job is being done for them. This can delay the natural development of bladder awareness at night.
The brain-bladder connection relies on a coordinated signalling system involving three parts:
Sometimes, this system doesn’t work perfectly. That can happen for a variety of reasons, like:
There are lots of other things that can also make it harder for the messages to work well — like being a deep sleeper, having sleep that gets interrupted a lot, having allergies, or even how you breathe at night.
When the brain and bladder aren’t in sync, the messages can get missed, delayed, or mixed up. And that’s when bedwetting is more likely to happen — especially while you’re asleep.
Sometimes, simply helping children understand how their brain and bladder work together is enough to shift things. When they realise their bladder is trying to send a message—and their brain can learn to listen and respond—they often start to message each other. Somehow, this just works! 🙌
Here are a few gentle ways to support that connection at home:
This playful approach helps build awareness. And once your child understands what’s going on inside their body, that brain and bladder connection often starts to strengthen on its own.
If you’d like some help with this, Stay Dry at Night offers gentle bedtime recordings that guide children through these ideas in a calm and reassuring way. We also support parents in exploring the many reasons a child might be wetting the bed—so that you can help set your child up for success.
If you’re not quite ready to jump into the full program just yet, that’s okay. We’ve got a FREE guide to help you take the first gentle step.
If you’d like to support your child by helping them start to build that brain–bladder messaging system, this guide will walk you through how to begin. It’s practical, easy to follow, and designed for parents who want to understand what’s going on—and what they can do to help.
You’ll learn:
👇 Click below to access your free guide: Your Quick & Easy First Step to Stop Bedwetting
The brain and bladder connection is often the missing piece in understanding bedwetting. When the brain doesn’t recognise or act on bladder signals during sleep, accidents happen. However, this internal communication can be strengthened – with time, practice, and the right support.
What’s encouraging is that progress can sometimes come quickly. And when it doesn’t, it’s not a sign of failure—just a sign that your child needs a little more time and support—or that there is another part to completing the bedwetting jigsaw puzzle.
If your child is still wetting the bed, it may simply be that this connection is still developing. With patience—and a clear understanding of how to support that process—your child can build this communication system. And dry nights can become more frequent, more consistent, and eventually, just a normal part of life.
ERIC. (n.d.). Interoception and toileting. ERIC – The Children’s Bowel & Bladder Charity. https://eric.org.uk/interoception-and-toileting/
Anna P Malykhina (2017) Urodynamics: How the brain controls urination eLife 6:e33219 https://doi.org/10.7554/eLife.33219
Ginny Laver BA (Hons), MSc, NLP, Dip. THP is a Clinical Hypnotherapist and Neuro Linguistic Programming (NLP) practitioner who specialises in helping children learn how to stop bedwetting naturally.
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